The ADA gene provides instructions for producing the enzyme adenosine deaminase. This enzyme is produced in all cells, but the highest levels of adenosine deaminase are found in immune system cells called lymphocytes. These cells defend the body against foreign invaders, such as viruses or bacteria. Lymphocytes are produced in specialized lymphoid tissues throughout the body, including in a gland located behind the breastbone called the thymus and in the lymph nodes.
The function of the adenosine deaminase enzyme is to get rid of a molecule called deoxyadenosine, which is generated when DNA is broken down. A buildup of deoxyadenosine in cells can lead to early cell death. Adenosine deaminase converts deoxyadenosine to another molecule called deoxyinosine, which is not harmful.
Other Names
ADA_HUMAN; adenosine aminohydrolase
Related Genetics Topics
Identifiers
- NCBI Gene: 100
- OMIM: 608958
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
