The AKR1D1 gene provides instructions for making an enzyme called 3-oxo-5-beta(β)-steroid 4-dehydrogenase. This enzyme is found in liver cells. It participates in the production of bile acids, which are a component of a digestive fluid called bile. Bile acids stimulate bile flow and helps absorb fats and fat-soluble vitamins. Bile acids are produced from cholesterol in a multi-step process. The 3-oxo-5-β-steroid 4-dehydrogenase enzyme is responsible for the third step in that process, which converts 7alpha(α)-hydroxy-4-cholesten-3-one to 7α-hydroxy-5β-cholesten-3-one.
Other Names
3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; 5-beta-reductase; AK1D1_HUMAN; aldo-keto reductase family 1, member D1; delta 4-3-ketosteroid-5-beta-reductase; delta(4)-3-ketosteroid 5-beta-reductase; delta(4)-3-oxosteroid 5-beta-reductase; SRD5B1; steroid 5-beta-reductase
Related Genetics Topics
Identifiers
- NCBI Gene: 6718
- OMIM: 604741
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
