The AKT3 gene provides instructions for making a protein that is most active in the nervous system. The AKT3 protein is a key regulator of a chemical signaling pathway called the PI3K-AKT-mTOR pathway. This signaling influences many critical cell functions, including the creation (synthesis) of new proteins, cell growth and division (proliferation), and the survival of cells. The PI3K-AKT-mTOR pathway is essential for the normal development of many parts of the body, including the brain. Studies suggest that the AKT3 protein plays a critical role in determining brain size.
Other Names
PKB gamma; PKB-GAMMA; PKBG; PRKBG; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-PK-gamma; STK-2; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Related Genetics Topics
Identifiers
- NCBI Gene: 10000
- OMIM: 611223
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
