The AMER1 gene provides instructions for making a protein found in tissues throughout the body where it helps regulate the Wnt signaling pathway, which is a series of chemical signals that affect the way cells and tissues develop. Wnt signaling is important for cell division, attachment of cells to one another (adhesion), cell movement (migration), and many other cell activities. The AMER1 protein can promote cell growth by helping to turn on (activate) the Wnt pathway or prevent cell growth by helping to turn off (repress) the Wnt pathway. When repressing the pathway, the AMER1 protein is acting as a tumor suppressor, which means that it helps prevent cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.
Other Names
adenomatous polyposis coli membrane recruitment 1; FAM123B; family with sequence similarity 123B; FLJ39827; OSCS; protein FAM123B; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX
Related Genetics Topics
Identifiers
- NCBI Gene: 139285
- OMIM: 300373
- OMIM: 300647
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
