The ANTXR2 gene provides instructions for making a protein that is found at the surface of many types of cells. The ANTXR2 protein is believed to interact with components of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. This matrix strengthens and supports connective tissues, such as skin, bone, cartilage, tendons, and ligaments.
The ANTXR2 protein is involved in the formation of tiny blood vessels (capillaries). It may also be important for maintaining the structure of basement membranes, which are thin, sheet-like extracellular matrix structures that separate and support cells in many connective tissues. Research suggests that the ANTXR2 protein aids in the breakdown of at least one type of extracellular matrix protein, ensuring the correct balance of proteins is maintained for normal functioning of muscles and connective tissues.
The ANTXR2 protein also acts as a receptor for the toxin that causes anthrax, allowing the toxin to attach to cells and trigger disease.
Other Names
anthrax toxin receptor 2; ANTR2_HUMAN; capillary morphogenesis protein 2; CMG-2; CMG2; FLJ31074; ISH; JHF; MGC111533; MGC45856
Related Genetics Topics
Identifiers
- NCBI Gene: 118429
- OMIM: 608041
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
