The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). The NF-κB protein complex regulates the activity of multiple genes, including genes that control the body’s immune responses and inflammatory reactions. Inflammation is a normal immune system response to injury and foreign invaders (such as bacteria). The NF-κB protein complex also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).
The CARD14 protein is found in many of the body’s tissues, but it is particularly abundant in the skin. NF-κB signaling appears to play important roles in regulating inflammatory reactions in the skin and in promoting the survival of skin cells.
Other Names
bcl10-interacting maguk protein 2; BIMP2; CAR14_HUMAN; CARD-containing MAGUK protein 2; card-maguk protein 2; carma 2; CARMA2; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14
Related Genetics Topics
- Psoriatic arthritis — MedlinePlus Genetics
- Familial pityriasis rubra pilaris — MedlinePlus Genetics
- Generalized pustular psoriasis — MedlinePlus Genetics
Identifiers
- NCBI Gene: 79092
- OMIM: 607211
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
