The DNAH11 gene provides instructions for making a protein that is part of a larger group (a complex) of proteins called dynein. This complex functions within cell structures called cilia. Cilia are microscopic, finger-like projections that stick out (project) from the surface of cells. They are found in cells that line the airway, the reproductive system, and many other organs and tissues. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Dynein makes up the structures (arms) that produce the force needed for cilia to move.
Dynein forms structures known as inner dynein arms (IDAs) and outer dynein arms (ODAs) within the core of many cilia (the axoneme). Coordinated movement of the dynein arms causes the entire axoneme to bend back and forth. Within IDAs and ODAs, dynein is made up of different combinations of protein components (subunits) that are classified by weight as heavy, intermediate, or light chains. The DNAH11 gene provides instructions for making the heavy chain 11 protein, which is found in ODAs. Other subunits are produced from different genes.
Other Names
DNAHBL; DNAHC11; DPL11; dynein heavy chain beta-like; dynein, axonemal, heavy polypeptide 11; dynein, ciliary, heavy chain 11
Related Genetics Topics
Identifiers
- NCBI Gene: 8701
- OMIM: 603339
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
