The FRAS1 gene provides instructions for making a protein that is part of a group of proteins called the FRAS/FREM complex. This complex is found in basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. The FRAS/FREM complex is particularly important during development before birth. One of its roles is to anchor the top layer of skin by connecting the basement membrane of the top layer to the layer of skin below. The FRAS/FREM complex is also involved in the proper development of certain other organs and tissues, including the kidneys, although the mechanism is unclear.
Other Names
extracellular matrix protein FRAS1; FLJ14927; FLJ22031; Fraser syndrome 1; KIAA1500
Related Genetics Topics
- Anophthalmia/Microphthalmia — MedlinePlus Genetics
- Coloboma — MedlinePlus Genetics
- Fraser syndrome — MedlinePlus Genetics
- Congenital anomalies of kidney and urinary tract — MedlinePlus Genetics
Identifiers
- NCBI Gene: 80144
- OMIM: 607830
- OMIM: 610805
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
