The HSD3B7 gene provides instructions for making an enzyme called 3 beta-hydroxysteroid dehydrogenase type 7 (3β-HSD7). This enzyme is found in liver cells. It is embedded in the membrane of a cell structure called the endoplasmic reticulum, which is involved in protein processing and distribution. The 3β-HSD7 enzyme participates in the production of bile acids, which are a component of a digestive fluid called bile. Bile acids stimulate bile flow and helps absorb fats and fat-soluble vitamins. Bile acids are produced from cholesterol in a multi-step process. The 3β-HSD7 enzyme is responsible for the second step in that process, which converts 7alpha(α)-hydroxycholesterol to 7α-hydroxy-4-cholesten-3-one.
Other Names
3 beta-hydroxy-delta 5-C27-steroid oxidoreductase; 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; 3BHS7_HUMAN; c(27) 3-beta-HSD; C(27)-3BETA-HSD; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; SDR11E3; short chain dehydrogenase/reductase family 11E, member 3
Related Genetics Topics
Identifiers
- NCBI Gene: 80270
- OMIM: 607764
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
