The HSPB1 gene provides instructions for making a protein called heat shock protein beta-1. This protein is a member of the heat shock protein family, which helps protect cells that are under stress from factors such as infection, inflammation, exposure to toxins, elevated temperature, injury, and disease. Heat shock proteins block signals that lead cells to self-destruct (undergo apoptosis). In addition, they appear to be involved in cell movement, stabilizing the cell’s structural framework (the cytoskeleton), folding and stabilizing newly produced proteins, and repairing damaged proteins. Heat shock proteins also seem to play a role in the tensing of muscle fibers (muscle contraction).
Heat shock protein beta-1 is found in cells throughout the body, where it interacts with other proteins and primarily helps fold newly produced proteins and refold damaged proteins. In nerve cells (neurons), heat shock protein beta-1 helps to organize a network of molecular threads called neurofilaments that maintain the structure of a part of the neuron called the axon. This allows neurons to transmit nerve impulses efficiently.
Other Names
heat shock protein beta-1; HSPB1_HUMAN; SRP27; stress-responsive protein 27
Related Genetics Topics
- Charcot-Marie-Tooth disease — MedlinePlus Genetics
- Distal hereditary motor neuropathy, type II — MedlinePlus Genetics
Identifiers
- NCBI Gene: 3315
- OMIM: 602195
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
