The IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. This enzyme is found in mitochondria, which are the energy-producing centers within cells. Within mitochondria, the enzyme participates in reactions that produce energy for cell activities. Specifically, isocitrate dehydrogenase 2 normally converts a compound called isocitrate to another compound called 2-ketoglutarate. A series of additional enzymes further process 2-ketoglutarate to produce energy. The conversion reaction also produces a molecule called NADPH, which is necessary for many cellular processes and helps protect cells from potentially harmful molecules called reactive oxygen species.
Other Names
D2HGA2; ICD-M; IDH; IDHM; IDHP_HUMAN; IDP; IDPM; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
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Identifiers
- NCBI Gene: 3418
- OMIM: 137800
- OMIM: 147650
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
