The KCNJ5 gene provides instructions for making a protein that functions as a potassium channel, which means that it transports positively charged atoms (ions) of potassium (K+) into and out of cells. Potassium channels produced from the KCNJ5 gene are found in several tissues, including the adrenal glands, which are small hormone-producing glands located on top of each kidney. In these glands, the flow of ions creates an electrical charge across the cell membrane, which affects the triggering of certain biochemical processes that regulate aldosterone production. Aldosterone helps control blood pressure by maintaining proper salt and fluid levels in the body.
Other Names
cardiac ATP-sensitive potassium channel; CIR; G protein-activated inward rectifier potassium channel 4; GIRK4; heart KATP channel; inward rectifier K+ channel KIR3.4; IRK-4; KATP1; KIR3.4; LQT13; potassium channel, inwardly rectifying subfamily J, member 5; potassium inwardly-rectifying channel, subfamily J, member 5
Related Genetics Topics
- Romano-Ward syndrome — MedlinePlus Genetics
- Andersen-Tawil syndrome — MedlinePlus Genetics
- Familial hyperaldosteronism — MedlinePlus Genetics
- Aldosterone-producing adenoma — MedlinePlus Genetics
Identifiers
- NCBI Gene: 3762
- OMIM: 600734
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
