The KCNT1 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell’s ability to generate and transmit electrical signals.
Potassium channels are made up of several protein components (subunits). Each channel contains four alpha subunits that form the hole (pore) through which potassium ions move. Potassium channels can be made from four alpha subunits produced from the KCNT1 gene, or they can be made from subunits produced from both the KCNT1 gene and another gene called the KCNT2 gene.
The specific function of a potassium channel depends on its protein components and its location in the body. Channels that are made with the KCNT1 protein are active in nerve cells (neurons) in the brain, where they transport potassium ions out of cells. This flow of ions helps generate currents that activate (excite) neurons and send signals in the brain.
Researchers have determined that a molecule called PKC can increase the activity of channels that are made with the KCNT1 protein. While these channels can generate electrical currents without PKC, the currents are stronger when PKC attaches to the channel and increases the channel’s activity.
Other Names
KCa4.1; KIAA1422; potassium channel, sodium activated subfamily T, member 1; potassium channel, subfamily T, member 1; SLACK; Slo2.2
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Identifiers
- NCBI Gene: 57582
- OMIM: 608167
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
