The L1CAM gene provides instructions for producing the L1 cell adhesion molecule protein (shortened to L1 protein), which is found on the surface of nerve cells (neurons) throughout the nervous system. The L1 protein spans the cell membrane, with one end of the protein inside the cell and the other end projecting from the outer surface of the cell. This positioning allows the L1 protein to attach (bind) to other proteins, including other L1 proteins, on neighboring neurons to help these cells stick to one another (cell-cell adhesion).
The L1 protein plays a role in the movement (migration) and organization of neurons and the outgrowth of axons, which are specialized extensions of neurons that transmit nerve impulses. The protein also plays a role in the formation of the protective sheath (myelin) that surrounds certain neurons and the formation of junctions between nerve cells (synapses), where cell-to-cell communication occurs. These neuronal functions contribute to brain development, thinking ability, memory, and movement.
Other Names
antigen identified by monoclonal antibody R1; CAML1; CD171; L1CAM_HUMAN; MIC5; N-CAML1; neural cell adhesion molecule L1
Related Genetics Topics
Identifiers
- NCBI Gene: 3897
- OMIM: 307000
- OMIM: 308840
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
