The LPIN2 gene provides instructions for producing a protein called lipin-2. Researchers believe that this protein plays an important role in the processing of fats (lipid metabolism). It is also thought to help regulate inflammation, a normal immune system response to injury or infection.
Lipin-2 helps to regulate the activity of a complex called the NLRP3 inflammasome. Inflammasomes are groups of proteins that form in response to injury or infection. Once formed, the NLRP3 inflammasome sets off a series of events that trigger an inflammatory response. This response helps the body to fight the injury or infection.
Lipin-2 is also thought to be involved in bone remodeling, a normal process in which old bone is removed and replaced by new bone. Bones are constantly being remodeled, and this process is carefully controlled to ensure that bones stay healthy.
Other Names
CRMO1; LIPIN 2; MJDS; Phosphatidate phosphatase LPIN2
Related Genetics Topics
Identifiers
- NCBI Gene: 9663
- OMIM: 605519
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
