The MC2R gene provides instructions for making a protein called adrenocorticotropic hormone (ACTH) receptor. This protein is found primarily in the adrenal glands, which are hormone-producing glands located on top of each kidney.
The ACTH receptor is embedded in the membrane of cells where it attaches (binds) to ACTH. ACTH is a hormone that is released by the pituitary gland, located at the base of the brain. The binding of ACTH to its receptor triggers the adrenal glands to produce a group of hormones called glucocorticoids. These hormones, which include cortisol and corticosterone, aid in immune system function, play a role in maintaining normal blood sugar (glucose) levels, help trigger nerve cell signaling in the brain, and serve many other purposes in the body.
The ACTH receptor also likely plays a role in the development of the adrenal glands before birth.
Other Names
ACTH receptor; ACTHR; ACTHR_HUMAN; adrenocorticotropic hormone receptor; adrenocorticotropin receptor; corticotropin receptor; MC2 receptor; melanocortin 2 receptor (adrenocorticotropic hormone)
Related Genetics Topics
- Primary macronodular adrenal hyperplasia — MedlinePlus Genetics
- Familial glucocorticoid deficiency — MedlinePlus Genetics
Identifiers
- NCBI Gene: 4158
- OMIM: 607397
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
