The RACGAP1 gene provides instructions for making the Rac GTPase-activating protein 1. This protein is one of many proteins known as Rho GTPase activating proteins (GAPs). GAPs regulate the activity of proteins called GTPases, which play an important role in chemical signaling within cells.
Rac GTPase-activating protein 1 interacts with several other proteins during various stages of cell division. For example, this protein attaches (binds) with the protein produced from the KIF23 gene to form a complex called centralspindlin, which helps regulate the process by which dividing cells separate from one another (cytokinesis). Rac GTPase-activating protein 1 appears to be particularly important in the bone marrow, where the differentiation and development of red blood cells (erythropoiesis) occurs.
Other Names
CYK4; HsCYK-4; Male germ cell RacGap; MgcRacGAP
Related Genetics Topics
Identifiers
- NCBI Gene: 29127
- OMIM: 604980
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
