The RAF1 gene provides instructions for making a protein that is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell’s nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis).
The RAF1 gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.
Other Names
c-Raf; CRAF; Oncogene RAF1; raf proto-oncogene serine/threonine protein kinase; Raf-1; RAF1_HUMAN
Related Genetics Topics
- Bladder cancer — MedlinePlus Genetics
- Noonan syndrome — MedlinePlus Genetics
- Noonan syndrome with multiple lentigines — MedlinePlus Genetics
Identifiers
- NCBI Gene: 5894
- OMIM: 164760
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
