The RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Other Names
acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1T1; CBFA2T1; CDR; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; eight twenty one protein; ETO; MTG8; MTG8_HUMAN; myeloid translocation gene on 8q22; protein CBFA2T1; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); zinc finger MYND domain-containing protein 2; ZMYND2
Related Genetics Topics
Identifiers
- NCBI Gene: 862
- OMIM: 133435
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
