The SFRP4 gene provides instructions for making a protein called secreted frizzled-related protein 4 (SFRP4). This protein blocks (inhibits) a process called Wnt signaling. Wnt signaling plays an important role in the development of several tissues and organs throughout the body. In particular, regulation of this signaling process by SFRP4 is critical for normal bone development and remodeling. Bone remodeling is a normal process in which old bone is broken down and new bone is created to replace it. The SFRP4 protein also plays a role in the development of fatty (adipose) tissue.
Other Names
frizzled protein, human endometrium; FRP-4; FRPHE; PYL; secreted frizzled-related protein 4 precursor; secreted frizzled-related protein 4; secreted frizzled-related protein 4; sFRP-4
Related Genetics Topics
Identifiers
- NCBI Gene: 6424
- OMIM: 606570
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
