The SIX1 gene is part of a group of similar genes known as the SIX gene family. Genes in this family provide instructions for making proteins that bind to DNA and control the activity of other genes. Based on this role, SIX proteins are called transcription factors.
The SIX1 protein interacts with several other proteins, including the protein produced from the EYA1 gene, to regulate the activity of genes that are important for normal development. Before birth, these protein interactions appear to be essential for the normal formation of many tissues. These include the second branchial arch, which gives rise to tissues in the front and side of the neck; the ears; the kidneys; the nose; a gland called the thymus that is part of the immune system; and muscles used for movement (skeletal muscles).
Other Names
BOS3; homeobox protein SIX1; sine oculis homeobox (Drosophila) homolog 1; sine oculis homeobox homolog 1; sine oculis homeobox homolog 1 (Drosophila); SIX1_HUMAN; TIP39
Related Genetics Topics
- Branchiootorenal/branchiootic syndrome — MedlinePlus Genetics
- Congenital anomalies of kidney and urinary tract — MedlinePlus Genetics
Identifiers
- NCBI Gene: 6495
- OMIM: 601205
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
