The SMARCE1 gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.
Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells.
The role of the SMARCE1 protein within the SWI/SNF complex is not completely understood.
Other Names
BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMCE1_HUMAN; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Related Genetics Topics
Identifiers
- NCBI Gene: 6605
- OMIM: 603111
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
