The SPRED1 gene provides instructions for making the Spred-1 protein, which helps control (regulate) the Ras/MAPK signaling pathway. The Ras/MAPK pathway is involved in the growth and division of cells (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).
The Spred-1 protein attaches (binds) to a protein called Raf, which is part of the Ras/MAPK pathway. The binding of the Spred-1 protein blocks the activation of Raf, stopping the signaling through the remainder of the Ras/MAPK pathway.
Other Names
EVH1/Sprouty domain containing protein; FLJ33903; hSpred1; NFLS; PPP1R147; SPRE1_HUMAN; spred-1; sprouty related, EVH1 domain containing 1; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Related Genetics Topics
Identifiers
- NCBI Gene: 161742
- OMIM: 609291
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
