The ZAP70 gene provides instructions for making a protein called zeta-chain-associated protein kinase. This protein is part of a signaling pathway that directs the development of and turns on (activates) immune system cells called T cells. T cells identify foreign substances and defend the body against infection.
The ZAP70 gene is important for the development and function of several types of T cells. These include cytotoxic T cells (CD8+ T cells), whose functions include destroying cells infected by viruses. The ZAP70 gene is also involved in the activation of helper T cells (CD4+ T cells). These cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.
Other Names
FLJ17670; FLJ17679; SRK; STD; syk-related tyrosine kinase; TZK; ZAP-70; ZAP70_HUMAN; zeta chain of T cell receptor associated protein kinase 70kDa; zeta chain of T-cell receptor associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Related Genetics Topics
Identifiers
- NCBI Gene: 7535
- OMIM: 176947
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
