Nonsyndromic congenital nail disorder 10

Nonsyndromic congenital nail disorder 10 is a condition that affects the fingernails and toenails. Affected individuals have extremely thick nails (onychauxis) that separate from the underlying nail bed (onycholysis) and can appear claw-like. Some fingers and toes may be missing part of the nail (hyponychia).

In affected individuals, the nails are often abnormal from birth. However, the abnormalities may not be noticeable until later in childhood because the nails tend to grow more slowly than normal.

Individuals with nonsyndromic congenital nail disorder 10 do not have any other health problems related to the condition.

Other names

Claw-shaped nails; Nail disorder, nonsyndromic congenital, 10; NDNC10; Onychauxis, hyponychia, and onycholysis

Inheritance pattern

Autosomal recessive

Related genes

FZD6

Source: MedlinePlus Genetics, U.S. National Library of Medicine.