Trimethylaminuria

Trimethylaminuria is a disorder in which the body is unable to break down trimethylamine, a chemical compound that has a pungent odor. Trimethylamine has been described as smelling like rotten or decaying fish. As this compound builds up in the body, it causes affected people to give off a strong fishy odor in their sweat, urine, and breath. The intensity of the odor may vary over time. The odor can interfere with many aspects of daily life, affecting a person's relationships, social life, and career. Some people with trimethylaminuria experience depression and social isolation as a result of this condition.

Other names

Fish malodor syndrome; Fish odor syndrome; Stale fish syndrome; TMAU; TMAuria

Inheritance pattern

Autosomal dominant

Related genes

FMO3

Source: MedlinePlus Genetics, U.S. National Library of Medicine.