The ABCB11 gene provides instructions for making a protein called the bile salt export pump (BSEP), which is found in the liver. Bile salts are a component of bile that help the body digest fats. Bile salts are produced by liver cells and then transported out of the cell by the BSEP to make bile. The release of bile salts from liver cells is critical for the normal secretion of bile.
Other Names
ABC16; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; BRIC2; BSEP; PFIC2; PGY4; progressive familial intrahepatic cholestasis 2; sister of p-glycoprotein; SPGP
Related Genetics Topics
- Progressive familial intrahepatic cholestasis — MedlinePlus Genetics
- Benign recurrent intrahepatic cholestasis — MedlinePlus Genetics
Identifiers
- NCBI Gene: 8647
- OMIM: 603201
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
