The ACAD8 gene provides instructions for making an enzyme called isobutyryl-CoA dehydrogenase (IBD). This enzyme is found in mitochondria, the energy-producing centers inside cells. The IBD enzyme is involved in breaking down proteins from food. Specifically, this enzyme is responsible for the third step in the breakdown of a protein building block (amino acid) called valine. The IBD enzyme converts a molecule called isobutyryl-CoA into a molecule called methacrylyl-CoA. Other enzymes further break down methacrylyl-CoA into molecules that cells can use for energy.
Other Names
ACAD-8; ACAD8_HUMAN; Activator-recruited cofactor 42 kDa component; acyl-CoA dehydrogenase family, member 8; acyl-coenzyme A dehydrogenase 8; ARC42; FLJ22590
Related Genetics Topics
Identifiers
- NCBI Gene: 27034
- OMIM: 604773
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
