The ADAMTS3 gene provides instructions for making an enzyme that is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. The ADAMTS3 protein is part of a family of proteins that help process procollagen molecules. Procollagens are the precursors of collagens, which are complex molecules that add strength, support, and stretchiness (elasticity) to many body tissues.
Within the extracellular matrix, the ADAMTS3 enzyme works with another protein that is produced from the CCBE1 gene to help regulate the activity of a protein called vascular endothelial growth factor receptor 3 (VEGFR3). VEGFR3 plays a key role in the development and maintenance of the lymphatic system, which is a network of vessels that transport white blood cells (lymphocytes), nutrients, and proteins in a fluid called lymph.
Other Names
ADAMTS-4; KIAA0366
Related Genetics Topics
Identifiers
- NCBI Gene: 9508
- OMIM: 605011
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
