The AMACR gene provides instructions for making an enzyme called alpha-methylacyl-CoA racemase (AMACR). This enzyme is found in the energy-producing centers in cells (mitochondria) and in cell structures called peroxisomes. Peroxisomes contain a variety of enzymes that break down many different substances, including fatty acids and certain toxic compounds. They are also important for the production (synthesis) of fats (lipids) used in digestion and in the nervous system.
In peroxisomes, the AMACR enzyme plays a role in the breakdown of a fatty acid called pristanic acid, which comes from meat and dairy foods in the diet. In mitochondria, AMACR is thought to help further break down the molecules derived from pristanic acid.
Other Names
2-methylacyl-CoA racemase; AMACR_HUMAN; AMACRD; CBAS4; RACE; RM
Related Genetics Topics
Identifiers
- NCBI Gene: 23600
- OMIM: 214950
- OMIM: 604489
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
