The ATP2A2 gene provides instructions for making an enzyme called sarco(endo)plasmic reticulum calcium-ATPase 2 (SERCA2). This enzyme belongs to a family of ATPase enzymes that helps control the level of positively charged calcium atoms (calcium ions) inside cells. SERCA2 is found in the endoplasmic reticulum inside the cell and in a related structure called the sarcoplasmic reticulum inside muscle cells. The endoplasmic reticulum is a structure that is involved in protein processing and transport. The sarcoplasmic reticulum assists with muscle contraction and relaxation by releasing and storing calcium ions. Calcium ions act as signals for a large number of activities that are important for the normal development and function of cells. SERCA2 allows calcium ions to pass into and out of the cell in response to cell signals.
Other Names
AT2A2_HUMAN; ATP2B; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; sarcoplasmic reticulum Ca(2+)-ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2
Related Genetics Topics
Identifiers
- NCBI Gene: 488
- OMIM: 108740
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
