The BICD2 gene provides instructions for making one of a family of proteins called golgins. Golgins help maintain the structure of a cell component called the Golgi apparatus, in which newly produced proteins are modified so they can carry out their functions.
The BICD2 protein is found in all cells. The protein attaches (binds) to a group of proteins called the dynein complex, turning it on (activating it) and helping it bind to other cellular materials for transport. During transport, BICD2 stabilizes the dynein complex along a track-like system of small tubes called microtubules, similar to a conveyer belt. The BICD2 protein helps the dynein complex with protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes.
In nerve cells (neurons), the BICD2 protein helps the dynein complex transport sac-like structures called synaptic vesicles. These structures contain chemical messengers that allow neighboring cells to communicate with one another.
Other Names
bA526D8.1; bic-D 2; bicaudal D homolog 2; coiled-coil protein BICD2; cytoskeleton-like bicaudal D protein homolog 2; homolog of Drosophila bicaudal D; KIAA0699
Related Genetics Topics
Identifiers
- NCBI Gene: 23299
- OMIM: 609797
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
