The CATSPER1 gene provides instructions for producing a protein that is found in the tail (flagellum) of sperm cells. The CATSPER1 protein plays a role in sperm cell movement (motility). It is one of four proteins that together form a hole (pore) that allows for the movement of charged calcium atoms (Ca2+) across the sperm cell membrane. Ca2+ is needed for a type of sperm motility called hyperactivation. Hyperactivation is characterized by vigorous movements of the sperm tail, which allow the sperm to push through the membrane of the egg cell during fertilization.
Other Names
cation channel, sperm associated 1; CATSPER; CTSR1_HUMAN; sperm ion channel; sperm-associated cation channel 1
Related Genetics Topics
Identifiers
- NCBI Gene: 117144
- OMIM: 606389
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
