The CFHR5 gene provides instructions for making a protein called complement factor H-related 5. The precise function of this protein is unknown. However, its structure is similar to that of a protein called complement factor H (which is produced from the CFH gene). This similarity provides clues to the probable function of complement factor H-related 5.
Complement factor H regulates a part of the body’s immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. This system must be carefully regulated so it targets only unwanted materials and does not damage the body’s healthy cells. Complement factor H helps to protect healthy cells by preventing the complement system from being turned on (activated) when it is not needed. Studies suggest that complement factor H-related 5 also plays a role in controlling the complement system.
Other Names
CFHL5; complement factor H-related 5; complement factor H-related protein 5; factor H-related protein 5; FHR-5; FHR5; FHR5_HUMAN; FLJ10549; MGC133240
Related Genetics Topics
- Atypical hemolytic-uremic syndrome — MedlinePlus Genetics
- C3 glomerulopathy — MedlinePlus Genetics
- Age-related macular degeneration — MedlinePlus Genetics
Identifiers
- NCBI Gene: 81494
- OMIM: 608593
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
