The CLRN1 gene provides information for making a protein called clarin 1. This protein is probably involved in normal hearing and vision. Clarin 1 has been found in several areas of the body, including sensory cells in the inner ear called hair cells. These cells help transmit sound and motion signals to the brain. This protein is also active in the retina, which is the light-sensing tissue that lines the back of the eye. Although the function of clarin 1 has not been determined, studies suggest that it plays a role in communication between nerve cells (neurons) in the inner ear and in the retina. Clarin 1 may be important for the development and function of synapses, which are junctions between neurons where cell-to-cell communication occurs.
Other Names
USH3; USH3A; USH3A_HUMAN; Usher syndrome 3A; Usher syndrome type 3 protein
Related Genetics Topics
Identifiers
- NCBI Gene: 7401
- OMIM: 606397
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
