The DLG4 gene provides instructions for making a protein that plays a role in nerve cells (neurons) in the brain. The DLG4 protein is found at synapses, which are the connections between neurons where cell-to-cell communication occurs. Connected nerve cells act as the “wiring” in the circuitry, carrying signals between the brain and the rest of the body. At synapses, the DLG4 protein interacts with other proteins to regulate a process called synaptic plasticity, which allows synapses to change and adapt over time in response to experiences. Synaptic plasticity is critical for learning and memory.
Other Names
discs large, drosophila, homolog of, 4; postsynaptic density 95; PSD95; SAP90; synapse-associated protein 90
Related Genetics Topics
Identifiers
- NCBI Gene: 1742
- OMIM: 602887
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
