The EPG5 gene provides instructions for making a protein that is involved in a cellular process called autophagy. This process recycles worn-out or unnecessary cell parts and breaks down certain proteins when they are no longer needed. Autophagy also helps cells use materials most efficiently when energy demands are high. During autophagy, materials to be recycled or removed are isolated in compartments called autophagosomes. The autophagosomes are then transported to cell structures called lysosomes that break down the materials. The EPG5 protein is important for the interaction between autophagosomes and lysosomes that allows the transfer of materials.
In addition to its role in autophagy, the EPG5 protein aids in the cell’s ability to recognize infection from foreign invaders such as bacteria and viruses. The protein transports molecules from these invaders within cells so they can interact with immune system proteins that trigger reactions to fight the infection.
Other Names
ectopic P granules protein 5 homolog; HEEW1; hEPG5; KIAA1632; VICIS
Related Genetics Topics
Identifiers
- NCBI Gene: 57724
- OMIM: 615068
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
