The F2 gene provides instructions for making a protein called prothrombin (also known as coagulation factor II). Coagulation factors are a group of related proteins that are essential for normal blood clotting (hemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss.
Prothrombin is made chiefly by cells in the liver. The protein circulates in the bloodstream in an inactive form until an injury damages blood vessels. In response to the injury, prothrombin is converted to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, the primary protein that makes up blood clots.
Thrombin is also thought to be involved in cell growth and division (proliferation), tissue repair, and the formation of new blood vessels (angiogenesis).
Other Names
coagulation factor II; coagulation factor II (thrombin); PT; RPRGL2; THPH1
Related Genetics Topics
Identifiers
- NCBI Gene: 2147
- OMIM: 176930
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
