The FLT4 gene provides instructions for making a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system. The lymphatic system produces and transports fluids and immune cells throughout the body. VEGFR-3 is turned on (activated) by two proteins called vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D). When VEGF-C and VEGF-D attach (bind) to VEGFR-3, chemical signals are produced that regulate the growth, movement, and survival of lymphatic cells.
Other Names
FLT41; fms-related tyrosine kinase 4; vascular endothelial growth factor receptor 3; VEGFR3; VGFR3_HUMAN
Related Genetics Topics
Identifiers
- NCBI Gene: 2324
- OMIM: 136352
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
