The FOXP2 gene provides instructions for making a protein that acts as a transcription factor, which means that it controls the activity of other genes. It attaches (binds) to the DNA of these genes at a region of the protein known as a forkhead domain. Researchers suspect that the FOXP2 protein may regulate the activity of hundreds of genes.
The FOXP2 protein is active in several tissues, including the brain, both before and after birth. Studies suggest that the FOXP2 protein plays a key role in the functioning of synapses, which are the connections between nerve cells (neurons) where cell-to-cell communication occurs. Specifically, this protein is important for synaptic plasticity, which is the ability of synapses to change and adapt to experience over time. Synaptic plasticity is necessary for learning and memory.
The FOXP2 protein appears to be essential for the normal development of speech and language. Researchers are working to determine which genes are influenced by the FOXP2 protein and how changes in their activity lead to abnormal speech and language development.
Other Names
CAG repeat protein 44; CAGH44; forkhead/winged-helix transcription factor; SPCH1; TNRC10; trinucleotide repeat containing 10
Related Genetics Topics
Identifiers
- NCBI Gene: 93986
- OMIM: 605317
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
