The FREM1 gene provides instructions for making a protein that is involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
The FREM1 protein is one of a group of proteins, including proteins called FRAS1 and FREM2, that interact during embryonic development as components of basement membranes. Basement membranes help anchor layers of cells lining the surfaces and cavities of the body (epithelial cells) to other embryonic tissues, including those that give rise to connective tissues (such as skin and cartilage) and the kidneys.
Other Names
BNAR; C9orf143; C9orf145; C9orf154; extracellular matrix protein QBRICK; FLJ25461; FRAS1-related extracellular matrix protein 1; FREM1_HUMAN; TILRR
Related Genetics Topics
- Manitoba oculotrichoanal syndrome — MedlinePlus Genetics
- Coloboma — MedlinePlus Genetics
- Congenital anomalies of kidney and urinary tract — MedlinePlus Genetics
Identifiers
- NCBI Gene: 158326
- OMIM: 608944
- OMIM: 608980
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
