The G6PC1 gene provides instructions for making an enzyme called glucose 6-phosphatase. This enzyme is found on the membrane of the endoplasmic reticulum, which is a structure inside cells that is involved in protein processing and transport. Glucose 6-phosphatase works together with the glucose 6-phosphate translocase protein (produced from the SLC37A4 gene) to break down a type of sugar molecule called glucose 6-phosphate. The breakdown of this molecule produces the simple sugar glucose, which is the primary source of energy for most cells in the body. The glucose 6-phosphatase enzyme is expressed (active) in the liver, kidneys, and intestines, and is the main regulator of glucose production in the liver.
Other Names
G-6-Pase; G6Pase; G6Pase-alpha; G6PC; G6PC_HUMAN; glucose-6-phosphatase; glucose-6-phosphatase alpha; glucose-6-phosphatase, catalytic subunit
Related Genetics Topics
Identifiers
- NCBI Gene: 2538
- OMIM: 613742
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
