Mannose-binding lectin deficiency

Mannose-binding lectin deficiency is a condition that affects the immune system. People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. Whether this deficiency makes affected individuals prone to recurrent infections is not clear.

People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. Individuals with this condition may also contract more serious infections such as pneumonia and meningitis. Depending on the type of infection, the symptoms caused by the infections vary in frequency and severity.

Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. In addition, affected individuals undergoing chemotherapy or taking drugs that suppress the immune system are especially prone to infections.

Other names

Mannose-binding lectin protein deficiency; Mannose-binding protein deficiency; MBL deficiency; MBL2 deficiency; MBP deficiency

Inheritance pattern

Pattern unknown

Related genes

MBL2

Source: MedlinePlus Genetics, U.S. National Library of Medicine.