Myopathy with deficiency of iron-sulfur cluster assembly enzyme

Myopathy with deficiency of iron-sulfur cluster assembly enzyme is an inherited disorder that primarily affects muscles used for movement (skeletal muscles). This condition does not usually affect other types of muscle, such as the heart (cardiac) muscle.

From early childhood, affected individuals experience extreme fatigue in response to physical activity (exercise intolerance). Mild exertion results in a rapid heartbeat (tachycardia), shortness of breath, and muscle weakness and pain. However, people with this condition typically have normal muscle strength when they are at rest.

Prolonged or recurrent physical activity causes more severe signs and symptoms, including a breakdown of muscle tissue (rhabdomyolysis). The destruction of muscle tissue releases a protein called myoglobin, which is processed by the kidneys and released in the urine (myoglobinuria). Myoglobin causes the urine to be red or brown. This protein can also damage the kidneys, in some cases leading to life-threatening kidney failure.

In most affected individuals, the muscle problems associated with this condition do not worsen with time. However, at least two people with a severe variant of this disorder have experienced progressive muscle weakness and wasting starting in childhood.

Other names

Hereditary myopathy with lactic acidosis; HML; Iron-sulfur cluster deficiency myopathy; Myoglobinuria due to abnormal glycolysis; Myopathy with deficiency of ISCU; Myopathy with deficiency of succinate dehydrogenase and aconitase; Myopathy with exercise intolerance, Swedish type

Inheritance pattern

Autosomal recessive

Related genes

ISCU

Source: MedlinePlus Genetics, U.S. National Library of Medicine.