The GSS gene provides instructions for making an enzyme called glutathione synthetase. Glutathione synthetase participates in a process called the gamma-glutamyl cycle. The gamma-glutamyl cycle is a sequence of chemical reactions that takes place in most of the body’s cells. These reactions are necessary for the production of glutathione, a small molecule made of three protein building blocks (amino acids). Glutathione protects cells from damage caused by unstable oxygen-containing molecules, which are byproducts of energy production. Glutathione is called an antioxidant because of its role in protecting cells from the damaging effects of these unstable molecules. Glutathione also helps process medications and cancer-causing compounds (carcinogens), and helps build DNA, proteins, and other important cellular components.
Other Names
gamma-L-Glutamyl-L-cysteine:glycine ligase (ADP-forming); glutathione synthase; GSH synthetase; GSHB_HUMAN; GSHS; MGC14098
Related Genetics Topics
Identifiers
- NCBI Gene: 2937
- OMIM: 601002
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
