The HBB gene provides instructions for making a protein called beta-globin. Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells. In adults, hemoglobin typically consists of four protein subunits: two subunits of beta-globin and two subunits of a protein called alpha-globin, which is produced from another gene called HBA. Each of these protein subunits is attached (bound) to an iron-containing molecule called heme; the iron in the center of each heme can bind to one oxygen molecule. The hemoglobin within red blood cells binds to oxygen molecules in the lungs. The red blood cells then travel through the bloodstream and deliver oxygen to tissues throughout the body.
Other Names
beta globin; beta-globin; HBB_HUMAN; hemoglobin beta gene; hemoglobin, beta; hemoglobin–beta locus
Related Genetics Topics
- Sickle cell disease — MedlinePlus Genetics
- Beta thalassemia — MedlinePlus Genetics
- Methemoglobinemia, beta-globin type — MedlinePlus Genetics
Identifiers
- NCBI Gene: 3043
- OMIM: 141900
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
