The HDAC8 gene provides instructions for making an enzyme called histone deacetylase 8. This enzyme is involved in regulating the structure and organization of chromosomes during cell division.
Before cells divide, they must copy all of their chromosomes. The copied DNA from each chromosome is arranged into two identical structures called sister chromatids. Sister chromatids are attached to one another during the early stages of cell division by a group of proteins called the cohesin complex. Later in cell division, the cohesin complex must be removed so the sister chromatids can separate, allowing one from each pair to move into each newly forming cell. Histone deacetylase 8 carries out a chemical reaction that helps remove the cohesin complex so it can be recycled for future cell divisions.
Researchers believe that histone deacetylase 8, as a regulator of the cohesin complex, also plays important roles in stabilizing cells’ genetic information, repairing damaged DNA, and controlling the activity of certain genes that are essential for normal development.
Other Names
CDA07; CDLS5; HD8; HDACL1; histone deacetylase-like 1; MRXS6; RPD3; WTS
Related Genetics Topics
Identifiers
- NCBI Gene: 55869
- OMIM: 300269
- OMIM: 309585
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
