The HOGA1 gene provides instructions for making the 4-hydroxy-2-oxoglutarate aldolase (HOGA) enzyme. This enzyme is found in liver and kidney cells, specifically within structures called mitochondria, which are the energy-producing centers in cells. The HOGA enzyme is involved in breaking down a protein building block (amino acid) called hydroxyproline. Specifically, during the breakdown process, HOGA cuts (cleaves) a substance called 4-hydroxy-2-oxoglutarate to produce two smaller substances called pyruvate and glyoxylate. In mitochondria, pyruvate is likely involved in energy production, but the function of glyoxylate is unclear.
Other Names
DHDPS2; DHDPSL; dihydrodipicolinate synthase-like, mitochondrial; dihydrodipicolinate synthetase homolog 2
Related Genetics Topics
Identifiers
- NCBI Gene: 112817
- OMIM: 613597
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
