The IKBKG gene provides instructions for producing one piece (subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Nuclear factor-kappa-B is a protein complex that binds to DNA and controls the activity of other genes.
When the IKK protein complex is in the resting state (inactive), nuclear factor-kappa-B and the IKK complex are attached (bound) together. In response to certain chemical signals, the IKK complex releases nuclear factor-kappa-B.
The IKBKG protein plays a regulatory role in the IKK complex. Once the IKBKG protein is turned on (activated), it activates the other proteins in the complex, which in turn releases nuclear factor-kappa-B. The loose nuclear factor-kappa-B then moves into the nucleus of the cell and binds to DNA.
Nuclear factor-kappa-B regulates the activity of multiple genes, including genes that control the body’s immune responses and inflammatory reactions. Nuclear factor-kappa-B also appears to play a role in the signaling pathway that is critical for the formation of ectodermal tissues, including the skin, hair, teeth, and sweat glands. In addition, it protects the cell from certain signals that would otherwise cause it to self-destruct (undergo apoptosis).
Other Names
FIP-3; FIP3; Fip3p; IKK-gamma; IP2; NEMO; NEMO_HUMAN; NF-kappa-B essential modulator; ZC2HC9
Related Genetics Topics
- Incontinentia pigmenti — MedlinePlus Genetics
- Anhidrotic ectodermal dysplasia with immune deficiency — MedlinePlus Genetics
Identifiers
- NCBI Gene: 8517
- OMIM: 300248
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
