The IL31RA gene provides instructions for making a protein called interleukin-31 receptor alpha subunit (IL-31RA). This protein is one piece (subunit) of the IL-31 receptor, which is embedded in the cell membrane of many types of cells throughout the body.
At the cell surface, the IL-31 receptor interacts with a protein called interleukin 31 (IL-31). The receptor and IL-31 fit together like a lock and its key, triggering a series of chemical signals inside the cell. These signals stimulate itching (pruritus) and an immune system response called inflammation, although the mechanism is not completely understood.
Other Names
class I cytokine receptor; CRL; CRL3; cytokine receptor-like 3; GLM-R; GLMR; gp130-like monocyte receptor; GPL; hGLM-R; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31RA; PLCA2; PRO21384; soluble type I cytokine receptor CRL3; zcytoR17
Related Genetics Topics
Identifiers
- NCBI Gene: 133396
- OMIM: 609510
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
